The Handbook of Health and Migration in Latin America and the Caribbean is a relevant and important tool for all stakeholders, providing a precise mapping of the current context in the region related to migration health. With relevant input from the experts and updated, high-quality data, it will allow the development of evidence-based policies and person-centered actions plans toward more inclusive health services in the region. The handbook recognizes the main existing challenges and gaps, including the limited access to migrant-specific data from the health systems and the need to strengthen a more robust regional joint agenda on migration health. With an interdisciplinary approach, the handbook provides guidelines on how to enhance cross-border cooperation, improve operational mechanisms to better prevent, detect and respond to health threats, and finally develop the needed capacities to guarantee mobility-sensitive health systems. From a social, economic, and public health perspective, providing access to health care to all populations is the most efficient and wise way forward.