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Fe is an essential micronutrient, required for many biological processes. Apart from its role in O2 transport through hemoglobin, it is central to many redox processes throughout the body. The long-chain polyunsaturated fatty acids (PUFA) docosahexaenoic acid (DHA; 22:6 n-3) is ubiquitously present in the plasma membrane of biological cells and is an essential macronutrient in mammals since it participates in a number of biological functions which are key for homeostasis maintenance. This chapter summarizes the interactive role of Fe and DHA in physiological situations and nutritional deficiencies and reveals that DHA stimulates Fe metabolism, with several studies suggesting that Fe deficiency is associated with an alteration in tissue fatty acid content and hypomyelination, which indicates a clear interaction between Fe and DHA metabolism.

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Interactions Between Omega-3 Fatty Acids and Iron

  • 章节

  • 发表日期：

    2025年

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  • Julio J. Ochoa,
  • María Puche-Juárez,
  • Jorge Moreno-Fernández,
  • Mario Pulido-Morán,
  • Juan M. Toledano,
  • Naroa Kajarabille,
  • Javier Díaz-Castro

摘要

Fe is an essential micronutrient, required for many biological processes. Apart from its role in O2 transport through hemoglobin, it is central to many redox processes throughout the body. The long-chain polyunsaturated fatty acids (PUFA) docosahexaenoic acid (DHA; 22:6 n-3) is ubiquitously present in the plasma membrane of biological cells and is an essential macronutrient in mammals since it participates in a number of biological functions which are key for homeostasis maintenance. This chapter summarizes the interactive role of Fe and DHA in physiological situations and nutritional deficiencies and reveals that DHA stimulates Fe metabolism, with several studies suggesting that Fe deficiency is associated with an alteration in tissue fatty acid content and hypomyelination, which indicates a clear interaction between Fe and DHA metabolism.