The main aim of the chapter was to emphasize the extraor- dinary importance of omega-3 fatty acids for human health today. However, we cannot undermine the importance of the rest of the essential nutrients. All the essential nutrients in adequate quantities and their bioavailability have also to be ensured for good health. It is also important to be conscious of anti-nutrients [1, 2] including long-term use of drugs, tobacco, toxic pollutants, heavy metals and our ability to completely detoxify and protect our body from any harmful effects [3]. In this chapter, we will attempt to briefly discuss these confounding factors on which the ultimate beneficial effects omega-3 fatty acids actually rests.