Leptospira species are long, thin, motile spirochetes that are responsible for causing a biphasic illness known as leptospirosis. The first phase of disease is characterized by an acute, nonspecific febrile illness that can be followed by a second phase of immune-mediated complications. Moderate and severe infection from Leptospira species bacteria causes significant morbidity and mortality worldwide. The infection is especially prevalent among young men who reside in resource-poor tropical countries. Given the variable presentations of the disease, its high burden in countries with limited resources, and complexities associated with securing a definitive diagnosis, leptospirosis is vastly underreported. Management of the infection includes treatment with antibiotics along with varying degrees of supportive care to address a wide range of associated complications.