Liver abscesses are relatively uncommon. The clinical presentation includes fever and right upper quadrant abdominal pain. The most common etiologic agents include Staphylococcus aureus, a variety of enteric gram-negative bacilli, and the protozoan parasite Entamoeba histolytica. In recent years, the observed increase in reported cases caused by Klebsiella pneumoniae has gained attention because of their association with metastatic complications. The management of a patient with a bacterial liver abscess almost always involves a drainage procedure followed by a relatively long course of intravenous antibiotics. Amoebic abscesses are managed medically using a combination of two amoebicides, one to treat the parenchymal liver infection and the other to eradicate any residual intraluminal (intraintestinal) amoeba. The management of a patient with an amoebic liver abscess does not typically require a drainage procedure for diagnostic or therapeutic purposes.