Hepatitis refers to inflammatory conditions of the liver that are caused by infectious, autoimmune, metabolic, neoplastic, or genetic etiologies. No matter the underlying cause, the presence of liver inflammation is typically first recognized when a patient is found to have elevated serum aminotransferases on routine blood testing. Infectious hepatitis can present acutely with symptoms of fevers, nausea, vomiting, and abdominal pain or can be picked up incidentally on routine screening of asymptomatic patients with previously undiagnosed chronic infection. A thorough history and physical examination can guide the diagnostic evaluation for determination of the causative pathogen. Patients with acute hepatitis due to hepatotropic or systemic viral infections are typically treated with supportive care measures, whereas patients with chronic hepatitis infection may benefit from antiviral therapy to reduce or prevent long-term complications.