This chapter provides a comprehensive review of applications of artificial intelligence (AI) in the specialty of periodontics. Periodontology is a discipline of dentistry focused on the diagnosis and management of gingival and periodontal diseases. AI technologies including machine learning algorithms have shown great potential in revolutionizing several facets of periodontal care. This chapter explores the present status of AI in periodontology, its potential advantages, challenges, and limitations, and outlines the future directions for research and clinical implementation.