The addition of mineral compounds, as a partial replacement of cement, to improve concrete performance has been studied for more than 50 years. Most recently, this approach has been revitalized in the context of sustainable development to reduce the carbon footprint of cement. Amongst all mineral additions, limestone fillers, blast furnace slag, and fly ash are still the most widely used supplementary cementitious materials. However, these additions offer limited supplies and new sources are needed to change this situation. Among these, the valorization of clay represents an important potential on a worldwide scale. To give clay mineral reactivity, various methods have been developed, including calcination. Thus, metakaolin, obtained by slow firing of kaolinite, has been the subject of numerous studies. Its use as a partial substitution of cement makes it possible to design various concretes with optimized performance and economy. This manuscript discusses the reported role of calcined clay as a partial replacement of cement on fresh, bulk, dimensional stability, transport, and durability properties of concrete.