Limestone calcined clay cement is a new type of cementitious material that is composed of limestone powder, calcined clay, and clinker. The main advantage of using this material as a standard and mainstream cement is because it is cost efficient and reduces CO2 emissions by 40%. Nano-silica contains a very high amount of SiO2 (over 99%) and can be used to produce a filling effect. The effect of the addition of nano-silica on concrete and cement is very desirous. Nano-silica helps in accelerating the cement hydration process, increasing the durability and compressive strength. Considering these desirable properties of LC3 and nano-SiO2, a series of experiments were conducted. The aim of this paper is to evaluate the effects of nano-SiO2 on LC3 and study the possible applications in practical implementations.