The use of supplementary cementitious materials constitutes one of the main strategies by the global cement industry to limit the global warming. In the Amazon region, between 1990 and 2018, cements were produced with 14–30% calcined kaolin and 5–10% limestone. Posteriorly, use of calcined clays and limestone was replaced only by limestone up to 25%. A solution for the region to reduce costs and improve environmental indicators would be the large-scale use of limestone calcined clay cements (LC3) with other calcined kaolin/limestone ratios. The objective was to investigate the feasibility of new blends from the ratio of calcined kaolin to limestone below 2 and clinker replacement percentages above 50%. The results point to the possibility of using a greater amount of limestone in LC3 compositions while incorporating less clinker and calcined kaolin, bringing environmental benefits with reducing production costs. Changes in Brazilian standards are necessary to include new compositions of LC3.