Tangible symbol sets typically consist of three-dimensional miniature objects or parts of objects that relate in some way to corresponding real-world referents. Various types of tangible objects have been used as communication symbols for nonverbal and minimally verbal people with severe disabilities. This chapter provides an overview of the literature on teaching people with severe disabilities to communicate using tangible symbols. Indications and contraindications for the use of tangible symbols are delineated. Factors to consider when implementing an intervention aimed at teaching the functional use of tangible symbols are discussed.