Utilization of the ABCDEF Bundle (Assess, prevent, and manage pain, both spontaneous awakening trials (SATs) and spontaneous breathing trials (SBTs), Choice of Analgesia and sedation, Delirium-assess, prevent, and manage, Early mobility and exercise, and Family engagement and empowerment) in the intensive care unit (ICU) promotes interprofessional care and improves patient outcomes. The pharmacist has a unique role engaging the family and assisting with implementation of the ABCDEF Bundle. Pharmacists conducted medication histories when compared to other health care practitioners have been shown to have a lower rate of errors. Having the family in addition to the patient present during medication reconciliation is key to obtaining the most accurate medication history. Deprescribing medications used temporarily in the ICU such as antipsychotics, stress ulcer prophylaxis, or sedatives is an important role of the pharmacist. The family can serve as a resource to clarify home medications and allow clinicians to feel more comfortable with deprescribing medications. Confirmation of a patient’s home medications with the family prior to reinitiation of important home medications is another way that the pharmacist interacts with the family. Having the family in addition to the patient present during discharge counseling by the pharmacist is imperative and has been reported to be helpful by pharmacists. Utilization of a pharmacist in a post-intensive care syndrome (PICS) or Post Acute COVID-19 Syndrome (PACS) is key as the medication reconciliation process including the family member can alleviate symptoms of PICS-F. This chapter describes the role of the pharmacist with family engagement and empowerment or post-intensive care syndrome-family (PICS-F).