This research explores the development of an Ethereum-based blockchain system aimed at combating counterfeit drugs within the pharmaceutical supply chain. By evaluating existing blockchain solutions and proposing a comprehensive framework, this study focuses on real-time tracking and verification of drug authenticity. The architecture leverages Ethereum’s decentralized ledger technology and smart contracts to enhance security, transparency, and efficiency among stake-holders, including manufacturers, distributors, and retailers. Key objectives include developing a robust implementation framework, and conducting feasibility studies to address practical challenges such as scalability and data privacy. This research proposes a continuous improvement model with a feasible user interface architecture which adapts emerging threats and technological advancements. Findings highlight the potential for blockchain to significantly enhance the integrity of the global drug supply chain, while also identifying limitations and future research directions.