The chapter analyzes the clinical results of an artificial neural network (ANN) that has been processed in order to improve the predictability of intracorneal ring segments (ICRS) implantation in keratoconus. The ANN to guide ICRS provides an increase in the visual acuity, reduction in the spherical equivalent and improvement in the optical quality of keratoconus patients. Artificial intelligence gives better results when compared with the manufacturer’s nomograms in terms of better corrected vision and reduction of the coma-like aberrations.