This chapter provides a description of the experiences of human rights practitioners working on the issue of disappearances in Mexico based on 33 in-depth interviews conducted in 2019. The interviews were aimed at understanding the participants’ experiences of working in a context where organised criminal groups (OCGs) perpetrate disappearances, including challenges they face in their work, and how the legal questions examined in Chaps. 2 – 4 impact their work in practice, if at all. After briefly discussing some of the geographic differences between experiences shared by participants, the experiences are summarised in three inter-related themes: uncertainty, pragmatism, and frustration. Each theme is described and illustrated with quotes from the interviews. Broadly speaking, the overarching themes correspond to a dimension of the participants’ experience: the context in which they work (uncertainty), the actions that they have taken and continue to take (pragmatism), and their emotional reaction (frustration). ‘Uncertainty’ is composed of several sub-themes: the lack of information; the complexity of the situation, including ongoing insecurity; and conceptual difficulties that include the legal classification of crimes and grasping the state’s responsibility. Uncertainty also creates several practical dilemmas. Second, ‘pragmatism’ describes the adaptation of working methods by participants, principally in response to the needs of relatives of the disappeared. Finally, ‘frustration’ describes the emotional reaction by participants to the context in which they work, the scale of the crisis, the perceived indifference by society, and the absence of tangible change in the situation despite significant achievements at legal and institutional levels. A summary of the themes and their relationship to each other indicates that the state’s actions and omissions lie at the intersection of all themes, illustrating the states’ complete protection failure.