This chapter provides a comprehensive overview of the relationship between various vitamins, minerals, and acne vulgaris. It discusses the roles of vitamins A, D, C, E, B3, and B12, along with minerals like zinc, sulfur, and selenium, in influencing acne development and treatment. The chapter highlights the benefits of certain vitamins and minerals in reducing inflammation, sebum production, and acne severity, while also noting the potential risk of acne-exacerbating effects from high Vitamin B12 levels. Understanding the complicated interactions between these nutrients and acne vulgaris can guide more effective treatment strategies.