Acne vulgaris is a chronic inflammatory skin condition primarily affecting the pilosebaceous units of the skin, which include sebaceous glands and hair follicles. It commonly occurs during adolescence, affecting about 90% of teenagers, but can persist into adulthood, particularly in women. The condition is classified into inflammatory (papules, pustules, nodules, cysts) and non-inflammatory (comedones) lesions. Pathogenesis involves increased sebum production, follicular hyperkeratinization, bacterial colonization, and inflammation. Androgens, especially during puberty, play a significant role in stimulating sebaceous glands. The bacterium Cutibacterium acnes contributes to inflammation and lesion formation through enzymatic activity and immune responses. Genetic predisposition, hormonal changes, diet, and environmental factors can influence acne severity. Treatment options range from topical agents (retinoids, antibiotics) to systemic therapies (isotretinoin, hormonal treatments) and lifestyle modifications, including proper skincare and dietary changes. Acne can have a profound psychosocial impact, affecting self-esteem, body image, and quality of life. Emerging therapies and research are focusing on understanding genetic factors, antibiotic resistance, and exploring alternative treatments like complementary medicine (All about Acne Vulga…).