Fast-evolving powder technologies are gaining new ground in pharmaceutical R&D thanks to emerging novel techniques enabling exceptional control over particle formation and tuning of powder properties. Alongside continuously upgrading techniques, such as spray-drying and supercritical fluids, novel cutting-edge technologies, namely 3D printing and particle replication in non-wetting templates (PRINT), are signaling the advent of a new era in the manufacturing of pharmaceutical dosage forms. This fast-moving progress will surely bring pharmaceutical R&D to unparalleled performances in the near future and shape new roadmaps toward personalized medicine.