This chapter explores the synergy of bioinspired design principles within Mechatronics to drive sustainability and innovation. It introduces interdisciplinary Mechatronics, discusses its adaptation toward EcoMechatronics, and presents the significance and methodology of this research. The chapter then discusses the importance and objectives of incorporating bioinspired designs, detailing both non-bioinspired and bioinspired paradigms and their comparative synergies. The research methodology section outlines the structured design process, emphasizing sustainability, ecosystem-based management, and applying circular economy principles. Additionally, the chapter highlights the integration of advanced and smart materials, technologies, and computational tools in facilitating effective bioinspired designs. Comprehensive case studies illustrate the practical applications of bioinspired design in environmental monitoring and medical devices. The chapter concludes by examining the best general practices in Mechatronics design and best practices of bioinspired design in Mechatronics, including pitfalls and research challenges, offering insights into the future potential of bioinspired approaches in sustainable engineering design.