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This is a case with preexisting hypothyroidism, who developed new-onset thyrotoxicosis after an extended period of receiving pembrolizumab for her cancer. This was associated with development of a goiter, worsening hyperthyroidism, and positive TSH receptor antibodies, all consistent with a diagnosis of Graves’ disease. Despite an extended course of methimazole therapy, her Graves’ disease remained suboptimally controlled, prompting her surgical thyroidectomy as definitive treatment.

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Graves’ Disease After Prolonged Immune Checkpoint Inhibitor Therapy

  • 章节

  • 发表日期：

    2025年

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  • Janki Patel,
  • Conor Best

摘要

This is a case with preexisting hypothyroidism, who developed new-onset thyrotoxicosis after an extended period of receiving pembrolizumab for her cancer. This was associated with development of a goiter, worsening hyperthyroidism, and positive TSH receptor antibodies, all consistent with a diagnosis of Graves’ disease. Despite an extended course of methimazole therapy, her Graves’ disease remained suboptimally controlled, prompting her surgical thyroidectomy as definitive treatment.