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This case demonstrates a patient with metastatic renal cell carcinoma who developed a severe, pruritic rash diagnosed as transient acantholytic dermatosis (TAD) following immunotherapy. Despite several unsuccessful treatments, dupilumab therapy provided substantial relief, resulting in complete resolution of the TAD symptoms and has sustained effect even after resuming immunotherapy for his cancer.

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Rapid Resolution of Refractory Immunotherapy-Related Transient Acantholytic Dermatosis with Dupilumab

  • 章节

  • 发表日期：

    2025年

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  • Melissa R. Laughter,
  • Ata S. Moshiri

摘要

This case demonstrates a patient with metastatic renal cell carcinoma who developed a severe, pruritic rash diagnosed as transient acantholytic dermatosis (TAD) following immunotherapy. Despite several unsuccessful treatments, dupilumab therapy provided substantial relief, resulting in complete resolution of the TAD symptoms and has sustained effect even after resuming immunotherapy for his cancer.