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We presented a case with metastatic lung adenocarcinoma who developed ICI-induced erosive oral lichen planus with a component of pemphigus vulgaris. Biopsy results demonstrated a lichenoid dermatitis with abundant colloid bodies along a subepidermal split, while direct immunofluorescence staining revealed immunoglobulin deposition between the epidermal keratinocytes. The patient responded well to corticosteroid treatment initially, but ultimately required methotrexate and mycophenolate mofetil for long-term clearance.

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Erosive Oral Lichen Planus with Pemphigus Vulgaris Post Immune Checkpoint Inhibitor Treatment

  • 章节

  • 发表日期：

    2025年

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  • Hannah Y. Wang,
  • Carlos A. Torres-Cabala,
  • Anisha B. Patel

摘要

We presented a case with metastatic lung adenocarcinoma who developed ICI-induced erosive oral lichen planus with a component of pemphigus vulgaris. Biopsy results demonstrated a lichenoid dermatitis with abundant colloid bodies along a subepidermal split, while direct immunofluorescence staining revealed immunoglobulin deposition between the epidermal keratinocytes. The patient responded well to corticosteroid treatment initially, but ultimately required methotrexate and mycophenolate mofetil for long-term clearance.