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This is a case with metastatic renal cell carcinoma on nivolumab/ipilimumab and cabozantinib who presented with progressively worsening diarrhea and was found to have duodenitis, rectal ulcer, and perianal fistula/fluid collection. He was treated with antibiotics, budesonide, and 3 doses of vedolizumab with significant symptom response and resolution of fistula on follow up imaging 3 weeks later. He was successfully resumed on cabozantinib and remained on nivolumab during the entire GI event.

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Rectal Ulcer and Perianal Fistula in a Cancer Patient on Immune Checkpoint Inhibitor Therapy

  • 章节

  • 发表日期：

    2025年

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  • Christine Catinis,
  • Nitish Mittal,
  • Maya Sarihan,
  • Abdullah Aleem,
  • Jianbo Wang,
  • Matthew T. Campbell,
  • Yinghong Wang

摘要

This is a case with metastatic renal cell carcinoma on nivolumab/ipilimumab and cabozantinib who presented with progressively worsening diarrhea and was found to have duodenitis, rectal ulcer, and perianal fistula/fluid collection. He was treated with antibiotics, budesonide, and 3 doses of vedolizumab with significant symptom response and resolution of fistula on follow up imaging 3 weeks later. He was successfully resumed on cabozantinib and remained on nivolumab during the entire GI event.