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We present a case of a Caucasian male in 50s with metastatic melanoma who developed immune checkpoint inhibitor (ICI)-induced bullous pemphigoid. Classic biopsy results will reveal subepidermal separation with lymphocytic and/or eosinophilic infiltrate, and positive serologic testing for BP180 and/or BP230 antibodies further support the diagnosis. Topical corticosteroids are a mainstay for mild disease, but severe disease may require a course of systemic corticosteroids with a steroid-sparing agent for long-term management, such as dupilumab to avoid prolonged use of steroids.

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Bullous Pemphigoid Post Immune Checkpoint Inhibitor Therapy

  • 章节

  • 发表日期：

    2025年

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  • Hannah Y. Wang,
  • Phyu Aung,
  • Anisha B. Patel

摘要

We present a case of a Caucasian male in 50s with metastatic melanoma who developed immune checkpoint inhibitor (ICI)-induced bullous pemphigoid. Classic biopsy results will reveal subepidermal separation with lymphocytic and/or eosinophilic infiltrate, and positive serologic testing for BP180 and/or BP230 antibodies further support the diagnosis. Topical corticosteroids are a mainstay for mild disease, but severe disease may require a course of systemic corticosteroids with a steroid-sparing agent for long-term management, such as dupilumab to avoid prolonged use of steroids.