Taking a 600m span arch bridge with embedded framework - Tian'e Longtan Bridge as an example, the study is conducted. The T-beam scheme with 12 spans and one connection is adopted for the building on the arch of this bridge. The combined stress of the building on the arch puts forward high requirements for the layout of the support. In response to its particularity, this article has conducted a special design for the main bridge support. Then, ABAQUS is used to establish a three-dimensional elastic-plastic model of the bridge, analyze the dynamic characteristics of the main bridge, use time history analysis method to analyze the seismic response of the bridge, and conduct seismic verification calculations on key sections such as the arch ribs and columns on the arch of the main bridge. The research results indicate that the first mode of vibration is lateral bending vibration outside the plane, indicating that the lateral stiffness of the structure is relatively small and prone to lateral instability during earthquakes. Therefore, attention should be paid to enhancing the lateral stiffness of the arch ribs or the transverse connection between the ribs in the design of large-span embedded framework rib arch bridges; The construction process of split ring pouring results in uneven initial stress distribution of the main arch rib section, which does not meet the assumption of a flat section. The bearing capacity of its section is different from that of a regular section, so the usual calculation method is no longer applicable. It is recommended to use the composite element method; Under the two seismic intensities of E1 and E2, both the main arch rib and column are within the safe range, and the energy demand ratio is greater than 1.