Taking Hejiang Yangtze River Bridge as the prototype, the trial design of an Ultra-high-Strength-Concrete Filled Steel Tube (UHSC-FST) arch bridge is conducted in this paper. Compared with the prototype bridge, the consumption of concrete and steel materials in UHSC-FST arch ribs are reduced by 14.3 and 4.4%, respectively; the axial force of the UHSC-FST arch ribs and the displacement at the arch crown under the most unfavorable load combinations are reduced by 3.3~10.9 and 5.7%, respectively; the ultimate load-bearing capacity of UHSC-FST arch rib is increased by 42.0%. It is indicated by the analysis results that UHSC-FST arch bridge has the possibility to be constructed in both technical and economical point views, and it is worth and necessary to be further studied on this topic.