Taking the stability of the high slope during the construction period of the Qingshui River Bridge as the research object, the strength discount factor method is adopted to carry out slope stability analysis. The simulation model of the slope is constructed using GTS/NX. The stability of the slope, the displacement of the excavation slope and the stress distribution pattern are derived from the simulation analyses during the construction phase. The results show that the slope is stable during construction. The heavy rainfall situation greatly impacts the natural slope after excavation, which leads to the local rock and soil body area shear stress exceeding the limit value. Slope anchors and anti-slip piles are proved to be effective slope protection measures. Meanwhile, the stability of the slope system is significantly improved after tensioning the anchor cables.