This chapter reviews the current body of research on yoga for substance use. The conceptual overview defines substance use and substance use disorder (SUD) as they are used diagnostically and clinically. The costs and cultural impact of substance use and SUD are reviewed. Mechanisms of change are briefly discussed, including the roles of mindfulness, improved mind-body connection, regulations of parasympathetic activation, increased distress tolerance, and improved ability to resist urges to use. The search methods and scope of the review are detailed. Research studies that are reviewed include randomized controlled trials, including those that compare yoga to routine treatment and treatment with yoga added as an adjunctive support, and yoga compared to alternative control conditions. Qualitative studies are also reviewed. Other reviews and meta-analyses exploring yoga for substance use are detailed. Overall, findings suggest that providing yoga to individuals with SUD in addition to treatment as usual allows them to develop new tools and skills (such as emotion regulation, distress tolerance, self-control for quitting, and emotional self-control) to manage their day-to-day struggles without substances. Offered in conjunction with standard treatment, yoga has the potential to accelerate the rehabilitation process. Conclusions and recommendations for future research are provided.