Standardization of yoga research methodology is an area of literature that is severely lacking, likely due to yoga’s rich historical and cultural contexts and vast number of conceptual frameworks. Currently, few formal guidelines exist to provide structure for future exploration of yoga and its benefits. Rigorous and nuanced research is needed to better understand the role that yoga can play in developing embodied ways of being. By following suggested recommendations for yoga research, interventionists can improve study quality and ability to compare and replicate findings. This chapter offers a brief history of yoga, explores existing standards for the manualization of yoga interventions, summarizes characteristics of prior yoga studies and reviews, and provides a comprehensive list of considerations for best practices in yoga research protocols.