In the management of NeuroEndocrine Tumors (NETs), the role of surgery with curative intent depends on the localization of the neoplasm and its characteristics (dimension/grade). Resectable Lung-NETs (L-NETs) are usually treated surgically as well as the majority of the Gastro-Entero-Pancreatic-NETs (GEP-NETs), apart from pancreatic lesions <2 cm that can be observed with adequate follow-up due to the morbidity and mortality associated with the intervention. If feasible to obtain R0 resections, small G1 L-NETs and GEP-NETs can be removed endoscopically (bronchoscopy/gastroscopy/colonoscopy). Functional L-NETs and GEP-NETs are resected to reduce the effects of the associated endocrine syndrome. The approach to functional/non-functional rare NETs (pituitary, head and neck, thyroid, thymus, adrenal, paraganglioma and pheochromocytoma, prostate, breast, and female genital tract) is evaluated case by case in high-volume referral centers through Multidisciplinary Tumor Boards.