Police officers often come into contact with persons with mental illnesses. They face a challenging task in understanding and responding to a crisis, which may be averted without the use of force and through calm and compassionate interaction. This is easier said than done when the situation demands a prompt response and appropriate body language when dealing with a person who is undergoing a mental health crisis. Mental health disorders include a wide range of other disorders, including clinical depression, anxiety disorders, bipolar disorder, dementia, attention-deficit/hyperactivity disorder, obsessive-compulsive disorder, and post-traumatic stress disorder. The police need a higher level of mental health literacy, anti-stigma training, and communication skills. This chapter discusses the role of identification and knowledge of mental health-related illnesses by police officers for effective law enforcement. It highlights the importance of compassionate interaction in building rapport and trust for sensitive and democratic policing. This chapter also presents real-life experiences of police officers on duty. It further studies the role of training programmes that simulate real-life scenarios, role-play exercises, and de-escalation techniques such as Crisis Intervention Team (CIT) training and Soft Skills that may play a crucial role in equipping police with the requisite expertise.