The research explores issues related to improving the legal regulation of various measures of liability in the field of entrepreneurial activities amidst new realities. The main challenge in this sector of public relations is that, in today’s conditions, the existing national normative legal framework requires refinement to align with the rapidly changing business environment at home and abroad. This issue is not merely theoretical and legal but also remains practically relevant, given the difficulties encountered in legal enforcement practices. A significant portion of these difficulties is procedural, linked to implementing procedures for holding individuals accountable for violations committed during entrepreneurial activities. Summarizing and analyzing existing legal enforcement practices in this realm of legal relations contribute to further refining the mechanisms of civil and administrative liability in entrepreneurship. In turn, this should enhance the effectiveness of addressing various pressing issues through the adoption of necessary economic and legal measures aimed at supporting entrepreneurs amidst new challenges but also noticeably improve the business climate in the country, fostering better conditions for conducting various forms of small, medium, and large-scale businesses.