The research aims to study the job satisfaction of doctors and paramedical personnel in public institutions of the Kyzylorda Region of Kazakhstan in the post-COVID period and identify factors affecting their increase, which can generally positively impact sustainable development. The considered region is characterized by complexity, recognized as an ecological disaster zone, enhanced by remote population areas that are difficult to access for medical care. These issues put forward a policy of caring for the region’s medical professionals, their status, and their level of satisfaction because medical workers are more vulnerable due to high workloads. The data were analyzed with the help of a survey among respondents, interviews with heads of public institutions, and statistical analysis. Out of 150 selected survey participants, 138 respondents represent public clinics in the region (92% of the research sample). The satisfaction of physicians was 59.1%, and the satisfaction of the paramedical personnel was 56%. Based on the research data, the authors conclude that the essential criteria for forming satisfaction and commitment to the work of public institutions’ medical workers in the Kyzylorda Region include remuneration (bonuses), professional development, and the possibility of combining jobs. This research, conducted in the post-pandemic period, identified factors that affect the job satisfaction of physicians and paramedical personnel working in public institutions in the Kyzylorda Region that have a negative ecological status.