The paper deals with the influence of the choice of material for the structural scheme of a multi-stored residential frame building on the behavior of the building when resisting the action of wind pulsation load. In the course of the study, a comparative analysis of floor accelerations for two variants of the structural design of the building frame was performed and the influence of the structural design of the building on the value of the maximum acceleration and resistance to pulsation wind load was evaluated. Residential multi-stored building with steel frame and residential multi-stored building with monolithic reinforced concrete frame were considered. Nowadays, the construction of steel-framed residential buildings is actively developing in the world and it is important to evaluate the comfort of people’s stay in such a building. In the course of the study, calculations of the structural system of the building are carried out, maximum floor accelerations are determined, conclusions are drawn about the influence of the material on the behavior of the frame and recommendations on the application of compensating measures are given. The steel-framed building is a frame-rod system and is a low-frequency building; the value of the first natural vibration frequency f1 does not exceed 0.2 Hz. To ensure the economic efficiency of construction has a reduced metal intensity and as a consequence, reduced mass, which reduces the resistance of the frame to the action of the pulsation component of the wind load and increases the value of the maximum acceleration. The article analyzes the reasons for reducing the resistance of the frame to the action of the pulsation component of the wind load and increases the value of the maximum acceleration for the building on the steel frame, which is associated with the structural features of the building and metal intensity, and proposed compensatory measures to ensure compliance with the requirement to ensure dynamic comfort.