This research concerns the complex analysis of ecosystem relations in territorial areas and has resulted in the identification and development of sustainability indicators with the attempt to promote actions aimed at the protection and valorisation of natural, cultural and identity heritage of the territory. The ultimate aim is to build scenarios and predictive models for monitoring the impact of transformations. The inspiring principle focuses on the growing awareness that natural ecosystems must be maintained in dynamic balances to ensure viable future growth through the provision of goods and services based on the logic of ecosystem services. The research work has as its objective the improvement of the quality of life and includes aspects relating to the environmental, social and cultural well-being of citizens linked to a better use of the categories of ecosystem services (life support, supply, regulation of cultural lore). In particular, from an infra- and intra-generational ecological perspective, a strengthening of identity values ​​is expected, of the usability of the natural and cultural heritage of smaller urban centers and internal areas, of the quality of green and blue infrastructures aimed at sustainable use of territorial and environmental resources. The expected results are measured on the basis of the key indicators established by the European Commission to monitor the diffusion of innovation at a regional level.