This chapter develops an innovative framework for cultural studies and comparative culturology by integrating cross-cultural management, sociopolitical theory, philosophy, and social sciences. In a globalized world, the intersection of media culture, political economy, and organizational strategy is crucial for shaping consumer behavior, institutional operations, and corporate branding. Within Western capitalist democracies, media narratives influence sociopolitical resilience, necessitating an in-depth analysis of their representational politics, psychological effects, and managerial relevance. Through a cross-cultural management perspective, the chapter explores how identity politics, economic forces, and digital transformation impact cultural production and consumption. As broadcasting and digital platforms converge into unified virtual spaces, organizations must navigate evolving cross-cultural challenges and market complexities. A multiperspectival critique is applied, with The Handmaid’s Tale and its 2017 adaptation serving as case studies on global themes of power, gender, and governance. Building on Kellner’s Cinema Wars (2010) and Media Culture (1995[2020]), this work highlights the polysemic nature of media narratives and their strategic significance. By bridging cultural studies with cross-cultural management, it provides a compelling framework for business leaders, policymakers, and academics, offering insights into globalization’s complexities and fostering adaptable, inclusive, and forward-thinking enterprises in an ever-changing sociopolitical and economic landscape.