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The lipid-based chronic disease (LBCD) model is a novel mechanism for clinical use in the management of patients with elevated lipid values. The four stages of LBCD are risk, pre-disease (abnormal lipoprotein synthesis), disease (dyslipidemia), and complications (e.g., atherosclerosis). The main drivers of LBCD are inherent, but lifestyle factors can play a significant role in the progression of LBCD. Certain inherent factors can lead to LBCD stage 3 since birth, and the focus will be to prevent progression to LBCD stage 4 in these patients. Lifestyle interventions can help mitigate the impact of LBCD and should be incorporated into all stages of LBCD. The LBCD model provides a practical guide for early lifestyle intervention and progression of the disease.

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The Novel Lipid-Based Chronic Disease Model in Lifestyle Medicine: Impact on Prevention of Atherosclerotic Cardiovascular Disease

  • 章节

  • 发表日期：

    2025年

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  • Waqas A. Malick,
  • Robert S. Rosenson,
  • Ishan Naidu,
  • Jeffrey I. Mechanick

摘要

The lipid-based chronic disease (LBCD) model is a novel mechanism for clinical use in the management of patients with elevated lipid values. The four stages of LBCD are risk, pre-disease (abnormal lipoprotein synthesis), disease (dyslipidemia), and complications (e.g., atherosclerosis). The main drivers of LBCD are inherent, but lifestyle factors can play a significant role in the progression of LBCD. Certain inherent factors can lead to LBCD stage 3 since birth, and the focus will be to prevent progression to LBCD stage 4 in these patients. Lifestyle interventions can help mitigate the impact of LBCD and should be incorporated into all stages of LBCD. The LBCD model provides a practical guide for early lifestyle intervention and progression of the disease.