The aim of this paper is to analyze geographic characteristics of urban regions that may have an effect, positive or negative, on Covid’s transmission. The overwhelming majority of articles found on urban design don’t seem to provide a unanimous answer. Therefore, a comparative analysis of Covid-19 cases at regional-level in Greece was made, to investigate geographic, urban and traffic characteristics which influence Covid-19 transmission. Results show that islands and cities in the southern parts of Greece seem to be sanitary safer. Moreover the greater the distance from a metropolitan center, the less Covid-19 cases were recorded. Finally accessibility of a city measured as “covered area” by car has also a positive effect on Covid-19 transmission. On the other hand urbanization at the regional level and density at the city-level did not correlate with Covid-19 cases.