This paper explores the integration of the Physical Internet (PI) into the supply chain (SC) resilience literature, and proposes a protocol framework aligned with fundamental Internet principles to operationalize the PI. Unlike traditional hierarchical networks, the PI enables dynamic routing and collaboration, potentially increasing SC-resilience to disruptions. By adopting the TCP/IP protocol suite from the Internet, this study introduces protocols that address operational and resilience aspects of the PI. The analysis emphasizes the protocol's role in facilitating efficient and resilient SC-operations, and offers implications for improving SC-management in the context of the PI.