The modern food system faces pressing challenges such as population growth, environmental degradation, and food security concerns, necessitating innovative solutions for sustainable and safe food production. Nanobionics, integrating nanotechnology with biological systems, emerges as a transformative approach to enhance food safety, quality, and sustainability. This chapter explores the role of nanobionics in revolutionizing food science from field to fork. In agriculture, nanobionics improves crop production and quality through precision farming techniques and smart fertilizers, optimizing resource use while reducing environmental impact. Post-harvest, nanotechnology advances food preservation with intelligent packaging and nanopreservation techniques that extend shelf life and ensure food safety. Furthermore, nanobionics enhances food safety by enabling rapid detection of contaminants and pathogens, while also addressing consumer concerns through rigorous risk management and transparency. Sustainable practices, supported by nanobionics, offer solutions to reduce food waste and resource use, although challenges remain regarding environmental impacts and regulatory frameworks. Future trends highlight promising innovations poised to address global food security challenges.