This chapter explores the integration of systems thinking and artificial intelligence (AI) to enhance decision-making in complex environments. It outlines the conceptual frameworks that highlight the synergy between systems thinking and AI, illustrating how AI can complement and enhance systems thinking’s holistic approach. The chapter presents real-world case studies demonstrating successful applications of this integration and discusses the lessons learned from interdisciplinary implementations. A proposed dynamic model integrates AI with systems thinking to provide a comprehensive decision-support framework. This approach offers a robust solution for navigating complex systems and improving decision-making processes across various domains.