Utilizing acrylic acid and polyethylene glycol monomethallyl ether as primary polymerization monomers, with acrylamide partially substituting for acrylic acid, a series of polycarboxylate ether (PCE) were synthesized. The study delved into the influence of PCE on the flowability, time-dependent losses, mechanical properties, and apparent viscosity of cement pastes. Additionally, the dispersibility of PCE on slag powder was analyzed through the use of the MS2000 laser particle size analyzer. The findings reveal that PCE with a 30% substitution rate of acrylamide exhibits optimal performance. This is manifested by a low saturation dosage, minimal time-dependent losses, and an enhancement in the compressive strength of cement paste. Furthermore, at this substitution ratio, the dispersibility of slag particles is maximized. Nonetheless, it is noteworthy that the amide groups in PCE have an adverse effect on the apparent viscosity of cement paste.