In recent years, passenger and freight mobility are no longer addressed separately. As European cities are hardly pressed to transmit to smart and zero emission functional urban areas, mobility solutions and services are designed under one lens, supporting a strong inter-modal and inter- sectoral passenger and freight integration, in accordance with the “Green Paper on Urban Mobility” suggestions. Under this framework, the novel concept of “multimodal mobility hubs” has been put forward, proposing an innovative approach according to which, various sustainable transport modes are connected in a single location, for serving “last mile” delivery of people and goods, satisfying also needs of local communities. But, how can cities design, implement and operate successful and long-term multimodal hubs? Are there general design rules to be followed? Which is the appropriate location to be put in place? How accessibility and security are guaranteed? What governance and financing issues should be addressed? How the appropriate synergies can be achieved? In an effort to address these inquiries, the current study presents the Zero Emission Multimodal Mobility Hub (ZEMM-Hub) cycle, developed within the framework of MOVE21 EU2020 Horizon project, where different multimodal hubs were implemented and evaluated in three urban nodes of the Scandinavian TEN-T corridor. Based on insights and experience gained, the paper presents a methodology set up mainly inspired by the well-known Sustainable Urban Mobility Plan cycle. ZEMM-Hub cycle, aims to guide cities in designing and implementing hubs to reach their goals and transmit to smart and zero emission functional urban areas.