Improving urban mobility and quality of life are priorities for many cities worldwide. To address these challenges, the concept of “superblocks” has emerged as a potential model that seeks to reorganize urban space to create more human-centered areas. In this context, the following research examines the implementation of superblocks in Thessaloniki. It aims to investigate the perception and influence rate of Thessaloniki residents regarding implementing superblocks in their urban environment. For this purpose, a questionnaire that included basic questions related to the influence of superblocks in general and the implementation of a superblock in Thessaloniki was used. The survey results present evidence of the acceptance and effectiveness of superblocks in the Thessaloniki environment. In addition, they provide important information about the opinions and needs of the residents, highlighting the importance of understanding and considering these needs in urban planning. From the 165 people who answered the questionnaire, it was found that only 60.0% were aware of the concept of superblocks. After getting familiar with the concept in the frame of the questionnaire, it was found that such an intervention would be widely accepted, changing the travel habits of the participants. A percentage of 69.7% agree or strongly agree with the proposed intervention, while the vast majority, i.e., 93.9%, want green spaces, such as parks and gardens, in the place of the liberated public space.