One of the key challenges for modern cities is to achieve sustainable development, with equal opportunities for all residents at its core. A crucial aspect of urban sustainability is transportation, and in particular walking. Walking is the only transportation mode that is inclusive and accessible to all residents, a key indicator of the quality of life of citizens, that also determines how well people live city. Thus, ensuring safe and high-quality pedestrian routes for all citizens, and especially for those with reduced mobility, is a critical issue for cities. In populous cities with complex urban environments, such as the Municipality of Athens of Athens, where high population density, dense urban environment and diversity of land use are key features, achieving safe pedestrian routes, especially for people with reduced mobility, is even more challenging. Driven by the need to ensure that people with reduced mobility have equal opportunities in complex urban environment, such as that of Athens, herein is presented a methodology for the creation of a safe and accessible to all pedestrian route, connecting major transportation hubs and important urban points of interest through major urban roads.