The skin microbiome has become a focal point in the study of various skin diseases, and its potential for medical and cosmetic applications has gained significant attention. Skin microbiome manipulations have arisen as a new and exciting approach to combat skin conditions and to revolutionize skin care. Promising approaches include skin microbiome transplantation, skin bacteriotherapy, and the use of prebiotics, probiotics and postbiotics. Skin microbiome transplantation involves transferring a healthy individual’s microbiome to another person's skin to improve their skin condition. Similarly, skin bacteriotherapy utilizes selected cultivated microorganisms applied to the skin to yield positive effects for the host. Prebiotics are also widely adopted, as they have the ability to stimulate the growth of health-enhancing microbes on the skin. In recent years, these approaches have shown promise in combating common skin disorders and restoring skin health associated with microbiome imbalances. Research in this area has led to successful applications of complete microbiome transplants and single-strain treatments with favorable therapeutic outcomes. Nevertheless, challenges persist, and ongoing research aims to optimize these strategies for more effective and precise skin microbiome interventions. As knowledge grows, the manipulation of the skin microbiome will likely lead to transformative therapies and improved skin health.