Climate change presents a tough challenge to wildlife survival, disrupting ecosystems worldwide and pushing numerous species to the edge of existence. This chapter explores how climate change is endangering wildlife through habitat loss, altered behaviors, health risks, and extreme weather events. Rising temperatures and changing precipitation patterns disrupt ecosystems, forcing species to migrate and altering their breeding and feeding habits. Concurrently, changes in climate facilitate the spread of diseases among wildlife. Intensified extreme weather events exacerbate these challenges, destroying habitat and increasing mortality. As a result of such, human-wildlife interactions are also getting affected, resulting in crop damage, livestock depredation, life loss and injury to humans, retaliatory killings, and social disruption.