The early detection and continuous monitoring of tropical diseases are critical to mitigating their public health impact, particularly in resource-constrained regions. This chapter explores the transformative potential of biosensors and wearable technologies in enhancing diagnostic capabilities and improving disease management. These innovative tools enable rapid, accurate, and accessible malaria, dengue, and tuberculosis detection, facilitating timely interventions that significantly reduce morbidity and mortality. Advancements in biosensor technologies, including electrochemical, optical, and piezoelectric sensors, have expanded their applications, improving diagnostic device sensitivity, specificity, and portability. Further innovations in point-of-care testing, microfluidics, and nanotechnology have made these tools more user-friendly and efficient, enhancing their utility in remote and underserved areas. Wearable technologies also play a vital role by continuously monitoring vital health parameters and providing real-time disease surveillance. Devices integrating smart textiles, embedded sensors, and wireless communication systems allow for seamless data collection and connectivity with public health systems, empowering healthcare providers with actionable insights. These technologies are precious in managing tropical diseases in geographically isolated communities, offering a scalable solution to bridge healthcare gaps. Despite their immense potential, challenges persist, including technical limitations, economic barriers, user acceptance, and ethical concerns such as data privacy and equitable access. Addressing these issues requires ongoing research, capacity building, and strong international collaboration to ensure sustainable deployment and widespread adoption. Biosensors and wearable technologies align closely with the Sustainable Development Goals (SDGs), particularly SDG 3 (Good Health and Well-being) and SDG 9 (Industry, Innovation, and Infrastructure). By improving health outcomes, reducing disease burdens, and fostering innovation, these technologies represent a significant step toward achieving global health equity and resilience. With continued advancements and inclusive strategies, biosensors and wearables can revolutionize the management of tropical diseases and contribute to a healthier, more sustainable future.