It is estimated that over 100 million people worldwide are affected by the addicted behaviours of a close relative and often experience related adverse health and social outcomes. There are a range of interventions which involve affected family members. Whilst they are largely psychosocial in nature, they differ in their aim and approach. These interventions can largely be categorised as interventions that (1) work with the family to address problems within the family, (2) are focused on the person with addiction problems and include conjoint sessions that may also provide some support to the affected family member or (3) intervene directly with the affected family member only. This chapter discusses a range of different interventions that involve affected family members and provides an overview of the evidence. After considering the main interventions for affected family members, this chapter highlights that most available interventions do not go far enough in responding to the complex and multi-faceted needs of families affected by a relative’s addiction. A number of gaps in the evidence exist including estimation of effect using rigorous evaluative methods, interventions for male affected family members and culturally adapted interventions for affected family members from low- and middle-income countries. Further research is needed to determine the effect of a multi-component psychosocial intervention, which seeks to support both the person with addiction problems and the affected family member.