This chapter focusses on presenting the evidence base on the nature and consequences of stigma experienced by family members affected by substance use disorders, particularly in a health-care context, and leans on research focussing on addictions as well as other stigmatised health conditions. Stigma is a pervasive problem that associates an individual with negative attitudes and beliefs, leading to prejudice and discrimination towards them. These negative attitudes not only serve as a barrier to help-seeking, but they can also exacerbate the treatment gap for substance use disorders and worsen health and social outcomes for families in need of care. Disrupting stigma requires policymakers, health-care delivery stakeholders and communities to acknowledge stigma as a crucial barrier to care and commit to ways in which inclusive, family-centred and tailored approaches may be incorporated in policy and practice. There is a need for further exploration into designing and implementing context-relevant stigma-reduction interventions, identifying effective strategies for different populations and settings. We conclude this chapter with specific strategies that may be helpful to consider from a health-care and policy perspective.